Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury.

Results The increase in adenosine levels tended to be more pronounced in the subjects heterozygous for the AMPD1 34C > T variant (71 ± 22%, P =0.04), compared to placebo- (59 ± 29%, P =0.012) and caffeine-treated (53 ± 47%, P =0.29) subjects, but this difference between groups did not reach statistical significance.

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