Genetic variation in the tau protein phosphatase-2A pathway is not associated with Alzheimer's disease risk.

Discussion Genes harbouring markers with only modest evidence of association (nominally significant but not reaching the genome-wide significance threshold) can be identified if they belong to the same biological pathway or mechanism; therefore, pathway-based approaches, which jointly consider multiple variants in interacting or related genes, might complement the most-significant SNPs/genes approach for interpreting genome-wide association (GWA) data on complex diseases [ 7 , 8 ].

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