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Exploratory 7-Tesla magnetic resonance spectroscopy in Huntington's disease provides in vivo evidence for impaired energy metabolism.

J Neurol · 2011 · PMC3225625 · PMID 21614431

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Even so, despite this large range in disease burden score, a decline in absolute values of NAA and creatine was observed in the premanifest group, although this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.