Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus.

Consistent with earlier reports, we observed a 56% decrease in β-cells mass (p = 0.03) and an ∼8% increase in α-cell mass that did not reach statistical significance (p = 0.41) while somatostatin cell mass was similar (p = 0.68) in pancreas sections from patients with T2DM compared to controls ( Fig. 1a ) [14] , [15] , [16] .

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