Barely Significant
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Aged PROP1 deficient dwarf mice maintain ACTH production.

PLoS One · 2011 · PMC3228747 · PMID 22145038

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showed a trendno p-value reported
Although these N4 B6- Prop1 -/- mice showed a trend towards increased serum ACTH compared to wild type and heterozygote littermates, the difference was not significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.