A common complement C3 variant is associated with protection against wet age-related macular degeneration in a Japanese population.

In single-SNP analyses, two of the 13 SNPs showed nominally significant associations with wet AMD (rs2241394, nominal P = 8.32×10 −4 ; rs428453, nominal P = 0.0240), of which only rs2241394 withstood multiple test corrections (corrected empirical P = 0.0102; Bonferroni-corrected P = 0.0108, Table 2 ).

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