The non-protein coding breast cancer susceptibility locus Mcs5a acts in a non-mammary cell-autonomous fashion through the immune system and modulates T-cell homeostasis and functions.

The mammary epithelium of untreated Mcs5a -resistant congenic rats as compared with susceptible congenic control rats had equal percentages of CD3 + T cells (Figure 5a ), of which CD4 + and CD8 + T cells were equal as well, but γδTCR + T cells showed a strong trend ( P = 0.055) toward overabundance (Figure 5a ).

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