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Heparanase is essential for the development of diabetic nephropathy in mice.

Diabetes · 2012 · PMC3237641 · PMID 22106160

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The difference between 24-h albumin excretion in SST0001-treated versus vehicle-treated mice was maintained on week 16 of the experiment as well, although it did not reach statistical significance (not shown).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.