A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.

For both validation sets, there was either a highly significant or near-significant concordance between tumors assigned as “mir-155 positive” by the HEK293 signature and those tumors assigned as “mir-155 positive” by the gastric-derived hsa-miR-155 expression signature (p = 5.8×10−7 for glioblastoma and p = 0.06 for ovarian cancer; chi-square test) ( Table S4 ).

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