Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis.

Arthritis Res Ther · 2011 · PMC3241357 · PMID 21291540

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borderline significanceno p-value reported

IgG and IgA anti-CCP2 predicted RA significantly in conditional logistic regression models odds ratio (OR) = 94.1, 95% confidence interval (CI) 12.7 to 695.4 and OR = 11.1, 95% CI 4.4 to 28.1, respectively, the IgM anti-CCP showed borderline significance OR = 2.5 95% CI 0.9 to 6.3.

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highly significantno p-value reported

The presence of IgG and IgA anti-CCP antibodies was highly significant compared with controls.

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did not reach statistical significanceno p-value reported

The sensitivity for IgG and IgA anti-CCP were highly significant in samples from pre-RA patients compared with controls, whereas IgM anti-CCP did not reach statistical significance (Table 3 ).

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