Barely Significant
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Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden.

Arthritis Res Ther · 2011 · PMC3241374 · PMID 21342502

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The number of autoantibodies per individual also increased the closer the individual got to the onset of symptoms, particularly during the last 3 years before disease onset; however, this change did not reach statistical significance.

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