showed a trendP =0.059
Kaplan–Meier curves showed a trend of significance regarding the association of miR-487b or miR-410 expression with overall survival ( P =0.059) and disease-free survival ( P =0.067) ( Supplementary Figure 1 ).
Kaplan–Meier curves showed a trend of significance regarding the association of miR-487b or miR-410 expression with overall survival ( P =0.059) and disease-free survival ( P =0.067) ( Supplementary Figure 1 ).
None of the upregulated miRNAs elicited a significant adjusted P -value, whereas 17 downregulated miRNAs displayed highly significant adjusted P -values as well as the highest fold change.
With regards to the high-risk group ( MYCN -amplified and non- MYCN- amplified stage 4 ⩾18 months), the marginal significance of overall survival may be owing to the low number of survivors at 5 years post diagnosis.