Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.

PLoS One · 2011 · PMC3246481 · PMID 22216283

Europe PMC DOI

hedged sentences

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closest p · 1.0× alpha

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boldest claim

The sentences

nominally significantp<0.05actually significant

Only 10 of the 100 random gene sets showed a nominally significant result (p<0.05) whichever test statistic was used (SUMSTAT or SUMSQ).

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highly significantno p-value reported

This approach could be strongly influenced by a few highly significant SNPs (occurring by chance in the GWA study) being present within the gene set.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.