Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.

Although there was a trend towards reduced levels of UCP1 and VDAC proteins, these differences did not reach statistical significance ( Fig. 5 , right ).

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However, quantitative analysis of cell surface area revealed a moderate but highly significant reduction in adipocyte size in Tk2 -/- mice ( Fig. 1B ).

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