Influence of preprandial vs. postprandial insulin glulisine on weight and glycaemic control in patients initiating basal-bolus regimen for type 2 diabetes: a multicenter, randomized, parallel, open-label study (NCT00135096).

The proportion of patients with a weight increase of >5% or >10% of their body weight from baseline to endpoint did not reach statistical significance for premeal vs. postmeal administration [>5%: 45% of patients in the premeal group and 36% of patients in the postmeal group, OR (95% CI) = 0.68 (0.43, 1.06), p = 0.085; >10% : 14% and 10% of patients, OR (95% CI) = 0.71 (0.36, 1.14), p = 0.334; respectively].

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