In patients who received allo-SCT (n=53), there was a trend for improved outcome in DNMT3A exon 23+ patients (DFS and OS medians not reached) as compared to DNMT3A exon 23- patients (median DFS, 19.1 months, p=0.15; median OS, 29.2 months, p=0.1) but the difference did not reach statistical significance (figure 4 ).
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Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
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