This low rate of discordant genotypes did not affect the results: 23 of the 28 SNPs reached statistical significance in the replicated data, and although 5 SNPs did not reach statistical significance possibly because of the small sample of controls, the allele frequencies from the microarray data and TaqMan data are virtually indistinguishable ( Figure S5 ), suggesting that a 1% genotyping error rate should have no impact on this analysis.
2
—
—
The sentences
The effect of this more stringent adjustment made 3 of the 281 SNPs borderline significant.