The degree of this epigenetic change seems to be of predictive value, since tumors with incomplete MGMT promoter methylation are reported to fail on temozolomide, while those with complete methylation show a significant trend to respond to this treatment [ 65 ].
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Volumetric and MGMT parameters in glioblastoma patients: survival analysis.
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We can further assume, in this context, that the extent of resection may not be significant, when it is expressed as a percentage of the initial volume, but it is probably the absolute volume of the tumor remnant, which is the determinant factor affecting the prognosis.