Moreover, the observation that analysis of rs4844610 in the replication sample only showed a trend toward association, whereas the LCR1 CNV showed significant association in both study populations, independently, further strengthens the hypothesis that the CR1 CNV likely explains the association initially observed in the GWAS.
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Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
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