Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.

A phase II trial testing 5-FU encapsulated in poly (L-D) lactide-co-glycolide in conjunction with radiation against radiation alone in recurrent malignant glioma showed a trend in favor of the encapsulated 5-FU arm, compared with the radiation alone arm, in median survival (15.2 vs 13.5 months). 36 Clear evidence of tumor necrosis was visible where the encapsulated 5-FU was deposited in the tumor.

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