ffar3 expression was also significantly decreased in ffar2 −/− mice, but, although we also observed a trend toward a reduced ffar2 expression in ffar3 −/− mice, this did not reach statistical significance. ffar2 knockout decreases GLP-1 content.
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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2.
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