A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.

hsCRP For hsCRP, strong association signals were detected in the previously described CRP gene (rs1205, p = 8.20×10 −30 ) and in the 3′ of APOC-I ( Apolipoprotein C-I ) gene (rs4420638, p = 7.12×10 −11 ) ( Figure 3C and 3D and Table 2 ), a well known determinant of serum hsCRP that did not reach statistical significance (p = 2.85×10 −5 ) in our initial scan (Stage 1) [25] .

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Specifically, we found a novel highly significant association between IL-6 expression levels and the ABO locus, with our top associated marker tagging the O allele.

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