Altered nuclear tRNA metabolism in La-deleted Schizosaccharomyces pombe is accompanied by a nutritional stress response involving Atf1p and Pcr1p that is suppressible by Xpo-t/Los1p.

Mol Biol Cell · 2012 · PMC3268726 · PMID 22160596

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quite significantno p-value reported

We believe that overcoming the Los1p limitation is quite significant in sla1-Δ cells, which lack pre-tRNA 3′ end protection and in which nuclear surveillance pre-tRNA 3′ end decay is active ( Maraia and Lamichhane, 2011 ).

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