Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis.

Diabetologia · 2012 · PMC3268972 · PMID 22189484

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borderline significantno p-value reported

2 d) with borderline significant risk reduction of 29% (pooled RR = 0.71 [95% CI 0.50, 1.00]).

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of borderline significanceno p-value reported

As a result, treatment effects that could not be detected or treatment effects of borderline significance in direct meta-analysis could be identified.

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borderline non-significantno p-value reported

The treatment effect between ACEI/ARB and other antihypertensive drugs, based on nine studies [ 18 , 21 , 25 , 27 , 28 , 36 , 38 , 44 , 45 ] ( n = 646 vs 640), was homogeneous ( χ 2 = 8.74, df = 8, p = 0.365, I 2 = 8.4%) with a borderline non-significant effect of 16% (pooled RR = 1.16 [95% CI 0.99, 1.39]; see Table 2 and Fig. 2f ).

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