Impact of changing trends in medical therapy on surgery for benign prostatic hyperplasia over two decades.

Korean J Urol · 2012 · PMC3272552 · PMID 22323970

Europe PMC DOI

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an increasing trendno p-value reported

Our results confirmed an increasing trend in α-blocker monotherapy and combination therapy with 5-α-reductase inhibitors after the 1990s, when medical therapy became widespread.

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showed a trendno p-value reported

The mean prostate volume showed a trend similar to that of mean age.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.