The buffer-insoluble Aβ 42 and Aβ 40 in Ad-VIP-injected mice (74.82±5.88 ng/mg protein and 61.15±5.36 ng/mg protein, respectively) was moderately reduced compared to the Ad-blank-injected mice (89.32±5.04 ng/mg protein, 76.50±8.27 ng/mg protein, respectively) and PBS-injected mice (85.19±5.31 ng/mg protein,74.24±2.92 ng/mg protein, respectively), but the difference did not reach statistical significance (Ad-VIP vs.
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VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice.
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