Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials.

Effects were moderate for recurrence, and slightly smaller (but still highly significant) for breast cancer mortality and overall mortality. 8-year breast cancer mortality was 21·1% for the taxane groups versus 23·9% for the control groups (absolute gain 2·8%, SE 0·9; RR 0·86, SE 0·04, 2p=0·0005); for overall mortality the absolute gain was similar.

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In these trials there was a significant trend towards greater efficacy with higher cumulative anthracycline dosage (χ 2 1 =8·0, 2p=0·005; figure 4A ).

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