16 It is noteworthy that the incidence of primary hepatic malignancy and metastatic tumors was increased in PER2 S662G2H : p53 R172H /+ (27.3%) and PER2 S662D2H : p53 R172H /+ mice (19.4%) compared with that in p53 R172H /+ mice (8.7%), although it did not reach statistical significance ( P =0.17) ( Table 1 ).
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The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis.
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0.1700