Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption.

Furthermore, protein expression of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC1α), a transcriptional coactivator that plays a key role in regulating a number of genes involved in energy metabolism ( 18 ), showed a trend toward a reduction in control-treated DIO mice ( P = 0.077) that was not apparent in myriocin-treated DIO mice ( Fig. 4 E ).

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