Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.

The results show a trend toward the rs13431652-G allele blunting the elevated expression conferred by the rs573225-G allele, although, because of the relatively small effects involved and the inherent variability in transient transfections, the decrease did not reach statistical significance.

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