Frontal lobe changes occur early in the course of affective disorders in young people.

BMC Psychiatry · 2012 · PMC3280164 · PMID 22264318

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did not reach statistical significanceno p-value reported

However, interestingly, grey matter changes within the amygdala and precuneus did not reach statistical significance for the more severe stage 2/3 group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.