Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

PLoS One · 2012 · PMC3283647 · PMID 22363673

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a strong trendp = 0.06so close (0.05 < p ≤ 0.1)

There was a strong trend (p = 0.06) toward higher serum HIV-1 RNA concentration in last-on-therapy samples from participants reaching a primary study endpoint (mean 87,264 copies/mL; range 35,227–216,219 copies/mL) compared with those who did not (mean 37,424 copies/mL; range 826–138,776 copies/mL).

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