A pathogenic mechanism in Huntington's disease involves small CAG-repeated RNAs with neurotoxic activity.

PLoS Genet · 2012 · PMC3285580 · PMID 22383888

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did not reach statistical significanceno p-value reported

However, a expanded polyglutamine expressing vector using CAA instead of CAG repeats (80*CAA), induced a mild toxic effect at the latter time-point that did not reach statistical significance ( Figure 1C ).

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