Functional complementation between transcriptional methylation regulation and post-transcriptional microRNA regulation in the human genome.

BMC Genomics · 2011 · PMC3287497 · PMID 22369656

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closest p · 0.0× alpha

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boldest claim

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highly significantP < 10 -15actually significant

We found a highly significant correlation between promoter CpG O/E and 3' UTR length (Spearman's ρ = 0.24; P < 10 -15 ), indicating that the negative correlation pattern between promoter region methylation and number of miRNA target sites still holds in mice.

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showed a trendno p-value reported

showed a trend of decreased level of methylation level in PMDs (partially methylated domains in IMR90 cell line, contiguous regions with an average methylation level less than 70%).

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