nominally significantP value < 0.05
When using cutoff value 0.05 to separate the genes into three gene sets (i.e., nominally significant genes were defined as those with gene-wise P value < 0.05), we found that the DEPgenes in the subnetwork had a significantly larger proportion of nominally significant genes in the GWAS dataset (Fisher's exact test, P = 4.13 × 10 -4 ) compared to the remaining genes.