A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.

Both the CD4 + ∶T Reg and the CD8 + ∶T Reg ratios were notably altered in the arm receiving daclizumab as compared to saline controls with the ratio of CD4 + ∶T Regs trending towards significance and the ratio of CD8 + ∶T Regs demonstrating a significant increase in the average percent change from baseline (p = 0.0757 and p = 0.0153, respectively).

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While these are also small studies, these results may be significant given that the expected progression-free survival is 6.9–8.2 months in this patient population [74] , [75] .

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