As in WT-mice, WT-chimeras and IFNγR peri KO mice tended to exhibit higher Treg:Th17 ratios compared to IFNγRKO-chimeras and IFNγR CNS KO mice; however these differences did not reach statistical significance.
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IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci.
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