IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice.

Serum creatinine in both the +/+ and +/- mice at 26 weeks was significantly (t > 3.6, p < 0.01) higher than the level in the same genotype at 18 weeks, whereas the difference in serum creatinine between 18 and 26 week old -/- mice was less pronounced and did not reach statistical significance (t = 2.2).

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While the presence of two defective γ3 heavy chain constant region alleles did not greatly reduce the titers of auto-antibodies of all IgG subclasses, this genotype was associated with highly significant reductions in IgG3 auto-antibodies specific for dsDNA and α-actinin.

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