Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice.

The degree of saturation of the different HF diets had no major influence on whole-body glucose tolerance, that is, all the HF diets reduced the clearance of glucose from the blood compared with the LF_PO ( Figures 4a and b ), although this did not reach statistical significance for HF_OO (+45.6% in HF_PO versus LF_PO, P <0.005; +38.5% in HF_CB versus LF_PO, P <0.022; +28.9% in HF_OO versus LF_PO, P =0.16; and +45.4% in HF_SO versus LF_PO, P <0.003).

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