Significant granzyme B secretion by 14.G2a-28 ζ gene-modified vs non-transduced T cells was found in response to both G D2 int (TC-71, TC-32) and G D2 low (VH-64, A4573, Cado-ES-1) cell lines, except for the lowest G D2 -expressing Ewing sarcoma cell lines WE-68, TTC-466 where responses did not reach statistical significance.
← all excerpts
The ganglioside antigen G(D2) is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting.
1
—
—