Allergic asthmatics show divergent lipid mediator profiles from healthy controls both at baseline and following birch pollen provocation.

However, a significant trend in elevated 15-LOX-derived compounds following provocation was observed (see below). 15-LOX metabolites and trend analysis Based upon the observed shifts in oxylipin levels described above, 15-LOX products were examined in further detail, both in terms of the sum of all potential 15-LOX metabolites (n = 15), as well as based upon their parent polyunsaturated fatty acid substrate divided as ω-6 (n = 10) and ω-3 (n = 5) fatty acids ( Table 2 , Figure 1 ).

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