A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer.

Nat Chem Biol · 2011 · PMC3306898 · PMID 21946274

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0.0001

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp< 0.0001actually significant

In addition, when all cells were pooled and subsequently treated with puromycin, a strong and highly significant (2-tailed t-test, p< 0.0001) depletion of the barcode associated with the puromycin-less vector was detectable whereas all other barcodes remained unchanged ( Supplementary Fig. 6 ).

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showed a trendp=0.07so close (0.05 < p ≤ 0.1)

This effect was specific as c-MYC amplified cells lines were not resistant for Aurora kinase inhibition but rather showed a trend towards synthetic lethality, which is in agreement with our previous findings ( Supplementary Fig. 26 , p=0.07).

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