However, the fraction of nanoparticles that may reach the brain via systemic circulation is expected to be rather low under healthy conditions, whereas the fraction translocated into the brain via sensory nerve endings in the olfactory bulb during inhalation may be quite significant in comparison ( Oberdörster et al. , 2004 ).
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Effects of silver nanoparticles on primary mixed neural cell cultures: uptake, oxidative stress and acute calcium responses.
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