Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.

There was a clear trend of inhibition of the metastatic dissemination of tumor cells into axillary lymph nodes of SCID mice as evaluated by the occurrence of metastasis (data not shown, 0/10 in Ang2-blocking group vs 4/10 in hIgG group) and the occurrence of cytokeratin-positive cells ( Figure 4, D ).

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