Lack of cortico-limbic coupling in bipolar disorder and schizophrenia during emotion regulation.

However, a near-significant trend emerged for a positive association between CPZ and activity in the right VLPFC of Sz during downregulation ( r =0.51, P =0.09); we note that this positive association cannot explain the group differences of hypoactivation of PFC regions in Sz during downregulation, relative to HC or BD groups (reported above), because any antipsychotic medication effects would have served to increase PFC activation in Sz, consistent with the desired therapeutic effects, but clearly in contrast to the effects reported here.

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With regard to the subjective emotional experience during each condition, only healthy participants' self-reported affect decreased significantly during downregulation, while a similar pattern in Sz and BD did not reach conventional levels of significance.

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