There was a substantial reduction of all four epidermal markers at the mRNA level as well as of CK6 and involucrin at the protein level in the Aire-deficient mice; whereas the changes for protein levels of CK10 and LEKTI in the Aire-deficient mice did not reach statistical significance (Figures 2 A,B).
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Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens.
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