Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice.

young mice Semiquantitative analysis of the burden of clustered immunoreactive puncta in the hippocampal formation of all 40 mice (i.e., 22 young and 18 aged mice) revealed a highly significant linear trend toward greater load in aged mice ( p < 0.0001 for each of LC3, p62, ubiquitin, MAP2, and synapsin IIa stainings; χ 2 test for linear trend [Fig. 3a–e ]).

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An inverse linear trend between the number of clusters of ubiquitin puncta and DR did not reach statistical significance ( ρ = −0.40, p = 0.098).

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