Alternative splicing and nonsense-mediated decay modulate expression of important regulatory genes in Arabidopsis.

This analysis shows that coupled AS/NMD can influence gene expression significantly and that even low abundant alternative transcripts (at steady state level) might turn over a quite significant proportion of the RNA produced from a gene. upf1-5, upf3-1 and cycloheximide treatment impair nonsense-mediated decay to different degrees More transcripts (102 transcripts) increased significantly in the upf3-1 mutant than in upf1-5 (47 transcripts) while 136 transcripts increased significantly in the cycloheximide-treated plants ( Figure 1 B).

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