Methamphetamine increases LPS-mediated expression of IL-8, TNF-α and IL-1β in human macrophages through common signaling pathways.

Although pretreatment of U937 macrophages with SC-514 prior to treatment with MA and LPS resulted in inhibition of IL-8 and IL-1β in terms of both protein or RNA, the repression of cytokine levels did not reach statistical significance (e.g.

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