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Crackle Pitch Rises Progressively during Inspiration in Pneumonia, CHF, and IPF Patients.

Pulm Med · 2012 · PMC3317011 · PMID 22530117

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a clear trendno p-value reported
While individual crackles vary in their pitch, there is a clear trend toward progressive increase in crackle pitch during inspiration: the average crackle pitch in this patient was 269 Hz in early, 317 Hz in mid, and 376 Hz in late-inspiration.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.